BRD-K91370081_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

298 genes differentially expressed following the BRD-K91370081_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
ANXA3 annexin A3
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD83 CD83 molecule
CDK17 cyclin-dependent kinase 17
CENPE centromere protein E, 312kDa
CEP350 centrosomal protein 350kDa
CHD9 chromodomain helicase DNA binding protein 9
CLK4 CDC-like kinase 4
CLTB clathrin, light chain B
COMP cartilage oligomeric matrix protein
CSRNP2 cysteine-serine-rich nuclear protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLC1 DLC1 Rho GTPase activating protein
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
ELF1 E74-like factor 1 (ets domain transcription factor)
ENO3 enolase 3 (beta, muscle)
FILIP1L filamin A interacting protein 1-like
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD5 frizzled class receptor 5
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFIH1 interferon induced with helicase C domain 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
INSM1 insulinoma-associated 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KIDINS220 kinase D-interacting substrate, 220kDa
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
LAMP3 lysosomal-associated membrane protein 3
LIMA1 LIM domain and actin binding 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MYO6 myosin VI
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDE8A phosphodiesterase 8A
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PER2 period circadian clock 2
PHACTR2 phosphatase and actin regulator 2
PHF20L1 PHD finger protein 20-like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSME4 proteasome (prosome, macropain) activator subunit 4
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RAB9A RAB9A, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SDC4 syndecan 4
SIRT1 sirtuin 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF7 serine/arginine-rich splicing factor 7
STAP2 signal transducing adaptor family member 2
STK38L serine/threonine kinase 38 like
TGFB2 transforming growth factor, beta 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TOMM34 translocase of outer mitochondrial membrane 34
TOX3 TOX high mobility group box family member 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
USP47 ubiquitin specific peptidase 47
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WDR47 WD repeat domain 47
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YTHDC1 YTH domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZBTB43 zinc finger and BTB domain containing 43
ZC3H11A zinc finger CCCH-type containing 11A
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZMYM5 zinc finger, MYM-type 5
ZNF160 zinc finger protein 160
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD10 abhydrolase domain containing 10
ADI1 acireductone dioxygenase 1
AHCY adenosylhomocysteinase
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
B3GNT1
BAG3 BCL2-associated athanogene 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C17ORF62 chromosome 17 open reading frame 62
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CKLF chemokine-like factor
CREG1 cellular repressor of E1A-stimulated genes 1
CRYZ crystallin, zeta (quinone reductase)
CSTA cystatin A (stefin A)
DCPS decapping enzyme, scavenger
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
DUT deoxyuridine triphosphatase
ECI2 enoyl-CoA delta isomerase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENDOD1 endonuclease domain containing 1
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HOXB6 homeobox B6
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYPLA1 lysophospholipase I
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
MLEC malectin
MLPH melanophilin
MOCS2 molybdenum cofactor synthesis 2
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MRPL16 mitochondrial ribosomal protein L16
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYCBP MYC binding protein
NAGA N-acetylgalactosaminidase, alpha-
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPEPL1 aminopeptidase-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRSS23 protease, serine, 23
PTDSS1 phosphatidylserine synthase 1
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB26 RAB26, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
REXO2 RNA exonuclease 2
RFC4 replication factor C (activator 1) 4, 37kDa
RNASET2 ribonuclease T2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMM50 SAMM50 sorting and assembly machinery component
SCARB1 scavenger receptor class B, member 1
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMELESS timeless circadian clock
TKT transketolase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM230 transmembrane protein 230
TMPO thymopoietin
TNNT1 troponin T type 1 (skeletal, slow)
TPGS2 tubulin polyglutamylase complex subunit 2
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TWF2 twinfilin actin binding protein 2
TXLNA taxilin alpha
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
URI1 URI1, prefoldin-like chaperone
VDAC3 voltage-dependent anion channel 3
WFS1 Wolfram syndrome 1 (wolframin)
XBP1 X-box binding protein 1