BRD-K91370081_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-K91370081_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGA aspartylglucosaminidase
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2A1 BCL2-related protein A1
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEMIP cell migration inducing protein, hyaluronan binding
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECD ecdysoneless homolog (Drosophila)
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4A2 eukaryotic translation initiation factor 4A2
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM179B family with sequence similarity 179, member B
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL11 interleukin 11
IL6 interleukin 6
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MOAP1 modulator of apoptosis 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1G metallothionein 1G
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
OXSR1 oxidative stress responsive 1
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAP1GAP2 RAP1 GTPase activating protein 2
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SUCO SUN domain containing ossification factor
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TFB2M transcription factor B2, mitochondrial
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBE2B ubiquitin-conjugating enzyme E2B
VCPKMT valosin containing protein lysine (K) methyltransferase
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ASRGL1 asparaginase like 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AUTS2 autism susceptibility candidate 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BPIFA1 BPI fold containing family A, member 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAV2 caveolin 2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CENPB centromere protein B, 80kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
COCH cochlin
COMT catechol-O-methyltransferase
CPT1A carnitine palmitoyltransferase 1A (liver)
CSTA cystatin A (stefin A)
CYB5R3 cytochrome b5 reductase 3
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM69A family with sequence similarity 69, member A
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
G6PD glucose-6-phosphate dehydrogenase
GSTP1 glutathione S-transferase pi 1
GTSE1 G-2 and S-phase expressed 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
KANK2 KN motif and ankyrin repeat domains 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0930 KIAA0930
KPNA3 karyopherin alpha 3 (importin alpha 4)
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LBR lamin B receptor
LHX2 LIM homeobox 2
MAP1B microtubule-associated protein 1B
MCM2 minichromosome maintenance complex component 2
MPZL2 myelin protein zero-like 2
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
NCOR2 nuclear receptor corepressor 2
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
OLFM4 olfactomedin 4
PAX6 paired box 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PIR pirin (iron-binding nuclear protein)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSCA prostate stem cell antigen
PTGIS prostaglandin I2 (prostacyclin) synthase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT11 septin 11
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNN stannin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TBC1D2B TBC1 domain family, member 2B
TBL1X transducin (beta)-like 1X-linked
TCF4 transcription factor 4
TMEM97 transmembrane protein 97
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
WSB2 WD repeat and SOCS box containing 2
ZBTB16 zinc finger and BTB domain containing 16