BRD-K91134378_Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone MLS-0083944.0001_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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24 genes differentially expressed following the BRD-K91134378_Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone MLS-0083944.0001_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CH25H cholesterol 25-hydroxylase
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
EPN2 epsin 2
IGFBP3 insulin-like growth factor binding protein 3
KRT14 keratin 14, type I
NDRG1 N-myc downstream regulated 1
SFN stratifin
STX1A syntaxin 1A (brain)
XPO7 exportin 7

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA2 annexin A2
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
CKS2 CDC28 protein kinase regulatory subunit 2
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ESRP1 epithelial splicing regulatory protein 1
GLIPR1 GLI pathogenesis-related 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
SPARC secreted protein, acidic, cysteine-rich (osteonectin)