BRD-K90999434_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K90999434_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN3 claudin 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENO2 enolase 2 (gamma, neuronal)
EZR ezrin
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LGALS8 lectin, galactoside-binding, soluble, 8
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
NAMPT nicotinamide phosphoribosyltransferase
NKG7 natural killer cell granule protein 7
NPC1 Niemann-Pick disease, type C1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
POR P450 (cytochrome) oxidoreductase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLPI secretory leukocyte peptidase inhibitor
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACACB acetyl-CoA carboxylase beta
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
C9ORF3 chromosome 9 open reading frame 3
CCND2 cyclin D2
CDC25A cell division cycle 25A
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
ECM1 extracellular matrix protein 1
EGF epidermal growth factor
FKBP5 FK506 binding protein 5
GLIPR1 GLI pathogenesis-related 1
GREM1 gremlin 1, DAN family BMP antagonist
HACD2 3-hydroxyacyl-CoA dehydratase 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
MOK MOK protein kinase
NOLC1 nucleolar and coiled-body phosphoprotein 1
PSPH phosphoserine phosphatase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFPQ splicing factor proline/glutamine-rich
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
WWP1 WW domain containing E3 ubiquitin protein ligase 1