BRD-K90700939_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K90700939_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CARS cysteinyl-tRNA synthetase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CRCT1 cysteine-rich C-terminal 1
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
GARS glycyl-tRNA synthetase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
KLF2 Kruppel-like factor 2
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LMO4 LIM domain only 4
LYPD1 LY6/PLAUR domain containing 1
MEA1 male-enhanced antigen 1
NRN1 neuritin 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PENK proenkephalin
PGD phosphogluconate dehydrogenase
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSAT1 phosphoserine aminotransferase 1
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
STC2 stanniocalcin 2
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AIM1 absent in melanoma 1
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCNB1 cyclin B1
CLDN8 claudin 8
CP ceruloplasmin (ferroxidase)
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
DTX4 deltex 4, E3 ubiquitin ligase
EPCAM epithelial cell adhesion molecule
EXPH5 exophilin 5
EXT1 exostosin glycosyltransferase 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO5 flavin containing monooxygenase 5
GOLM1 golgi membrane protein 1
GRB7 growth factor receptor-bound protein 7
HEBP1 heme binding protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
KRT19 keratin 19, type I
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYBPC1 myosin binding protein C, slow type
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS8 protease, serine, 8
PTRF polymerase I and transcript release factor
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RTN1 reticulon 1
SATB1 SATB homeobox 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395