BRD-K90417362_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K90417362_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP32 Rho GTPase activating protein 32
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
C5AR1 complement component 5a receptor 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD9 CD9 molecule
CHN2 chimerin 2
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
HPSE heparanase
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA0753 KIAA0753
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEX11A peroxisomal biogenesis factor 11 alpha
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRR15L proline rich 15-like
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEC63 SEC63 homolog (S. cerevisiae)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC12A8 solute carrier family 12, member 8
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
USP1 ubiquitin specific peptidase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHPT1 choline phosphotransferase 1
COL9A3 collagen, type IX, alpha 3
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DICER1 dicer 1, ribonuclease type III
DLC1 DLC1 Rho GTPase activating protein
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
ECI2 enoyl-CoA delta isomerase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
GPC3 glypican 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
IL6R interleukin 6 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT14 keratin 14, type I
LYPLA1 lysophospholipase I
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MYCBP MYC binding protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NR1D2 nuclear receptor subfamily 1, group D, member 2
PHACTR2 phosphatase and actin regulator 2
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRDX4 peroxiredoxin 4
PRR7 proline rich 7 (synaptic)
RPS11 ribosomal protein S11
SEPP1 selenoprotein P, plasma, 1
SOX9 SRY (sex determining region Y)-box 9
STK39 serine threonine kinase 39
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38