BRD-K90382497_GW-843682X_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K90382497_GW-843682X_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKAP8L A kinase (PRKA) anchor protein 8-like
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARG2 arginase 2
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIK BCL2-interacting killer (apoptosis-inducing)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CTH cystathionine gamma-lyase
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
H2BFS H2B histone family, member S (pseudogene)
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
IFRD1 interferon-related developmental regulator 1
KLF2 Kruppel-like factor 2
MFAP5 microfibrillar associated protein 5
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A3 nuclear receptor subfamily 4, group A, member 3
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRF1 perforin 1 (pore forming protein)
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
REXO2 RNA exonuclease 2
RHOB ras homolog family member B
RPA2 replication protein A2, 32kDa
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SOX17 SRY (sex determining region Y)-box 17
STAR steroidogenic acute regulatory protein
STK38L serine/threonine kinase 38 like
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ANO1 anoctamin 1, calcium activated chloride channel
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA12 carbonic anhydrase XII
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
ENSA endosulfine alpha
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HMBOX1 homeobox containing 1
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL9 kelch-like family member 9
LONP2 lon peptidase 2, peroxisomal
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MANSC1 MANSC domain containing 1
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MPZL2 myelin protein zero-like 2
NAV2 neuron navigator 2
NES nestin
NET1 neuroepithelial cell transforming 1
NGRN neugrin, neurite outgrowth associated
NISCH nischarin
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RHOBTB1 Rho-related BTB domain containing 1
RNASE4 ribonuclease, RNase A family, 4
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SULF1 sulfatase 1
TBX3 T-box 3
TF transferrin
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZBTB20 zinc finger and BTB domain containing 20