BRD-K90382497_GW-843682X_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K90382497_GW-843682X_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AGR2 anterior gradient 2
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CLGN calmegin
CLU clusterin
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MLPH melanophilin
MT1E metallothionein 1E
MYB v-myb avian myeloblastosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSBPL3 oxysterol binding protein-like 3
PIP prolactin-induced protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PROM1 prominin 1
RHOBTB3 Rho-related BTB domain containing 3
SESN1 sestrin 1
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNE2 cyclin E2
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
COL6A1 collagen, type VI, alpha 1
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DFNA5 deafness, autosomal dominant 5
DTX4 deltex 4, E3 ubiquitin ligase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD3 FXYD domain containing ion transport regulator 3
GPC3 glypican 3
GRK5 G protein-coupled receptor kinase 5
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
IFI16 interferon, gamma-inducible protein 16
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGSF3 immunoglobulin superfamily, member 3
IL6ST interleukin 6 signal transducer
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NUSAP1 nucleolar and spindle associated protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PGM1 phosphoglucomutase 1
PNMA2 paraneoplastic Ma antigen 2
PSIP1 PC4 and SFRS1 interacting protein 1
PSPH phosphoserine phosphatase
PXDN peroxidasin
REEP1 receptor accessory protein 1
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A11 S100 calcium binding protein A11
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNM synemin, intermediate filament protein
TMSB15A thymosin beta 15a
TNC tenascin C
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1