BRD-K90382497_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K90382497_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD44 CD44 molecule (Indian blood group)
CLGN calmegin
CLU clusterin
CXADR coxsackie virus and adenovirus receptor
CYCS cytochrome c, somatic
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
FHOD3 formin homology 2 domain containing 3
GRB7 growth factor receptor-bound protein 7
HSPA1A heat shock 70kDa protein 1A
LEF1 lymphoid enhancer-binding factor 1
LUM lumican
MAGEA1 melanoma antigen family A1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MET MET proto-oncogene, receptor tyrosine kinase
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NLRP2 NLR family, pyrin domain containing 2
OAT ornithine aminotransferase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLS3 plastin 3
PLXNA1 plexin A1
PRNP prion protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS13 regulator of G-protein signaling 13
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A10 S100 calcium binding protein A10
S100A13 S100 calcium binding protein A13
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TMSB15A thymosin beta 15a
TP63 tumor protein p63
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
UBE3C ubiquitin protein ligase E3C
UPP1 uridine phosphorylase 1
USP22 ubiquitin specific peptidase 22

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CHN2 chimerin 2
COL9A3 collagen, type IX, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CYBA cytochrome b-245, alpha polypeptide
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP7 fatty acid binding protein 7, brain
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
HDAC2 histone deacetylase 2
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLK7 kallikrein-related peptidase 7
MCUR1 mitochondrial calcium uniporter regulator 1
MEIS1 Meis homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
SIDT2 SID1 transmembrane family, member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
THBS4 thrombospondin 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WFDC2 WAP four-disulfide core domain 2