BRD-K89997465_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K89997465_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMPD3 adenosine monophosphate deaminase 3
ASPH aspartate beta-hydroxylase
C8ORF4 chromosome 8 open reading frame 4
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CTSH cathepsin H
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GPC3 glypican 3
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INSIG1 insulin induced gene 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MYO6 myosin VI
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK39 serine threonine kinase 39
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
EXOSC4 exosome component 4
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCA protein kinase C, alpha
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)