BRD-K89997465_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K89997465_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FBN2 fibrillin 2
FDPS farnesyl diphosphate synthase
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GRN granulin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
KRT20 keratin 20, type I
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MFSD10 major facilitator superfamily domain containing 10
MID1 midline 1
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAM peptidylglycine alpha-amidating monooxygenase
PCCA propionyl CoA carboxylase, alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HLF hepatic leukemia factor
HOXC6 homeobox C6
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
RACGAP1 Rac GTPase activating protein 1
RAD21 RAD21 homolog (S. pombe)
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASE4 ribonuclease, RNase A family, 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein