BRD-K89997465_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K89997465_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CAST calpastatin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD36 CD36 molecule (thrombospondin receptor)
CDK14 cyclin-dependent kinase 14
CHN1 chimerin 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MYO10 myosin X
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PNMA2 paraneoplastic Ma antigen 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF187 ring finger protein 187
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AREG amphiregulin
CD34 CD34 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A6 collagen, type IV, alpha 6
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
HBEGF heparin-binding EGF-like growth factor
HEATR1 HEAT repeat containing 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IRF1 interferon regulatory factor 1
KRT19 keratin 19, type I
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MED17 mediator complex subunit 17
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
OPHN1 oligophrenin 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PODXL podocalyxin-like
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VCL vinculin