BRD-K89930444_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-K89930444_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADAM9 ADAM metallopeptidase domain 9
ADGRG2 adhesion G protein-coupled receptor G2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
C6ORF48 chromosome 6 open reading frame 48
CAPN2 calpain 2, (m/II) large subunit
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
INHBB inhibin, beta B
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KDM6A lysine (K)-specific demethylase 6A
KLF5 Kruppel-like factor 5 (intestinal)
LAMB3 laminin, beta 3
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PAM peptidylglycine alpha-amidating monooxygenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTPRE protein tyrosine phosphatase, receptor type, E
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCRG1 stimulator of chondrogenesis 1
SDC1 syndecan 1
SERINC5 serine incorporator 5
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SRI sorcin
STC2 stanniocalcin 2
TAC1 tachykinin, precursor 1
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TMEM87A transmembrane protein 87A
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BAG3 BCL2-associated athanogene 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPM centromere protein M
CEP55 centrosomal protein 55kDa
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CXCL12 chemokine (C-X-C motif) ligand 12
DCXR dicarbonyl/L-xylulose reductase
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
EVL Enah/Vasp-like
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGHM immunoglobulin heavy constant mu
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCOLN1 mucolipin 1
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCNA proliferating cell nuclear antigen
PFKL phosphofructokinase, liver
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPDEF SAM pointed domain containing ETS transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TK1 thymidine kinase 1, soluble
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein