BRD-K89930444_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K89930444_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADRB2 adrenoceptor beta 2, surface
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CLDN3 claudin 3
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COMP cartilage oligomeric matrix protein
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FHL2 four and a half LIM domains 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
H1F0 H1 histone family, member 0
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1RAP interleukin 1 receptor accessory protein
INHBA inhibin, beta A
LARP6 La ribonucleoprotein domain family, member 6
MME membrane metallo-endopeptidase
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM176B transmembrane protein 176B
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VNN1 vanin 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AURKA aurora kinase A
CCNF cyclin F
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
COL3A1 collagen, type III, alpha 1
CTSC cathepsin C
CXCL9 chemokine (C-X-C motif) ligand 9
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FASTKD5 FAST kinase domains 5
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GPNMB glycoprotein (transmembrane) nmb
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF20A kinesin family member 20A
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
NTS neurotensin
NUP62 nucleoporin 62kDa
PAIP1 poly(A) binding protein interacting protein 1
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SRGN serglycin
STC1 stanniocalcin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UPK1B uroplakin 1B
ZMIZ1 zinc finger, MIZ-type containing 1