BRD-K89224880_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K89224880_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD3 abhydrolase domain containing 3
ADCY7 adenylate cyclase 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA10 annexin A10
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCAS1 breast carcinoma amplified sequence 1
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD14 CD14 molecule
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
KRT7 keratin 7, type II
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
MYO10 myosin X
NQO1 NAD(P)H dehydrogenase, quinone 1
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAC1 tachykinin, precursor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY9 adenylate cyclase 9
AIM1 absent in melanoma 1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX4 brain expressed, X-linked 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CEP57 centrosomal protein 57kDa
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
ESR1 estrogen receptor 1
FHL1 four and a half LIM domains 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
KCTD12 potassium channel tetramerization domain containing 12
KRT15 keratin 15, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MRPL15 mitochondrial ribosomal protein L15
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PEG10 paternally expressed 10
PLN phospholamban
RFC3 replication factor C (activator 1) 3, 38kDa
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2