BRD-K89224880_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K89224880_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
BLVRB biliverdin reductase B
CALR calreticulin
CBR3 carbonyl reductase 3
CENPE centromere protein E, 312kDa
CES1 carboxylesterase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLU clusterin
COLEC12 collectin sub-family member 12
CTSA cathepsin A
CTSL cathepsin L
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EGFR epidermal growth factor receptor
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPC1 glypican 1
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LPAR1 lysophosphatidic acid receptor 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP7 matrix metallopeptidase 7
MPP1 membrane protein, palmitoylated 1, 55kDa
MTF2 metal response element binding transcription factor 2
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
OPN3 opsin 3
PERP PERP, TP53 apoptosis effector
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAP1GAP RAP1 GTPase activating protein
RND3 Rho family GTPase 3
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOAT1 sterol O-acyltransferase 1
SQSTM1 sequestosome 1
STOM stomatin
TACC2 transforming, acidic coiled-coil containing protein 2
TALDO1 transaldolase 1
THBD thrombomodulin
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TKT transketolase
TNS1 tensin 1
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
ANXA6 annexin A6
ANXA9 annexin A9
AOX1 aldehyde oxidase 1
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CA9 carbonic anhydrase IX
CFB complement factor B
CREB3L1 cAMP responsive element binding protein 3-like 1
CTSE cathepsin E
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FBP1 fructose-1,6-bisphosphatase 1
FHL2 four and a half LIM domains 2
GCH1 GTP cyclohydrolase 1
HLF hepatic leukemia factor
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYZ lysozyme
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZK1 PDZ domain containing 1
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
PRSS23 protease, serine, 23
PXDN peroxidasin
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SF1 splicing factor 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TPBG trophoblast glycoprotein
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15