BRD-K89224880_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K89224880_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
COL6A2 collagen, type VI, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBN2 fibrillin 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
JUNB jun B proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KRT6A keratin 6A, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKM phosphofructokinase, muscle
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPARD peroxisome proliferator-activated receptor delta
PPL periplakin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PTK2 protein tyrosine kinase 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF167 ring finger protein 167
RPL39L ribosomal protein L39-like
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
BEX1 brain expressed, X-linked 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CNN1 calponin 1, basic, smooth muscle
COASY CoA synthase
CXCL12 chemokine (C-X-C motif) ligand 12
CYTH1 cytohesin 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP3 dual specificity phosphatase 3
EI24 etoposide induced 2.4
EREG epiregulin
FHL1 four and a half LIM domains 1
FLT3 fms-related tyrosine kinase 3
FNBP1 formin binding protein 1
FZD7 frizzled class receptor 7
GPX7 glutathione peroxidase 7
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
LAMP5 lysosomal-associated membrane protein family, member 5
LYPLA1 lysophospholipase I
MCM4 minichromosome maintenance complex component 4
MGLL monoglyceride lipase
MSH2 mutS homolog 2
MSH6 mutS homolog 6
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OLFM1 olfactomedin 1
PARP2 poly (ADP-ribose) polymerase 2
PBX3 pre-B-cell leukemia homeobox 3
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRDX2 peroxiredoxin 2
PRKCB protein kinase C, beta
PTDSS1 phosphatidylserine synthase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
SCG2 secretogranin II
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMF1 TATA element modulatory factor 1
TNS1 tensin 1
TOR1A torsin family 1, member A (torsin A)
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22