BRD-K89059493_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K89059493_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOLD1 apolipoprotein L domain containing 1
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK6 cyclin-dependent kinase 6
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
COL9A3 collagen, type IX, alpha 3
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD1 EH-domain containing 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HLA-B major histocompatibility complex, class I, B
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IL1RN interleukin 1 receptor antagonist
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LIF leukemia inhibitory factor
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NES nestin
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TSC22D1 TSC22 domain family, member 1
WDR1 WD repeat domain 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ATF5 activating transcription factor 5
BLNK B-cell linker
C3ORF14 chromosome 3 open reading frame 14
C5ORF30 chromosome 5 open reading frame 30
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHL1 cell adhesion molecule L1-like
COL1A1 collagen, type I, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8H golgin A8 family, member H
GYG2 glycogenin 2
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
LONP2 lon peptidase 2, peroxisomal
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL3 methyltransferase like 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP2 poly (ADP-ribose) polymerase 2
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
RSRP1 arginine/serine-rich protein 1
RUVBL1 RuvB-like AAA ATPase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TSPYL5 TSPY-like 5
USP34 ubiquitin specific peptidase 34
VCAN versican
ZNF302 zinc finger protein 302