BRD-K88742110_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K88742110_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALOX5 arachidonate 5-lipoxygenase
ANXA2 annexin A2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARG2 arginase 2
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN1 chimerin 1
CLEC7A C-type lectin domain family 7, member A
CLGN calmegin
CSF1R colony stimulating factor 1 receptor
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
DST dystonin
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
FGF2 fibroblast growth factor 2 (basic)
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP7 insulin-like growth factor binding protein 7
IL10RA interleukin 10 receptor, alpha
INHBE inhibin, beta E
ITGB7 integrin, beta 7
ITM2C integral membrane protein 2C
KIAA0907 KIAA0907
LAPTM5 lysosomal protein transmembrane 5
LOC100505650 uncharacterized LOC100505650
LY86 lymphocyte antigen 86
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYBPC1 myosin binding protein C, slow type
N4BP2L1 NEDD4 binding protein 2-like 1
NCF2 neutrophil cytosolic factor 2
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIR pirin (iron-binding nuclear protein)
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
RNASE6 ribonuclease, RNase A family, k6
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYT1 synaptotagmin I
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TPP1 tripeptidyl peptidase I
TRAF3IP3 TRAF3 interacting protein 3
TTN titin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHD7 chromodomain helicase DNA binding protein 7
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
EFNB2 ephrin-B2
ELF1 E74-like factor 1 (ets domain transcription factor)
ELN elastin
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM63A family with sequence similarity 63, member A
FNDC3B fibronectin type III domain containing 3B
FST follistatin
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KAT6B K(lysine) acetyltransferase 6B
KLF10 Kruppel-like factor 10
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN1 perilipin 1
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SMAD3 SMAD family member 3
SON SON DNA binding protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB2 transducer of ERBB2, 2
TSPAN13 tetraspanin 13
TSPAN5 tetraspanin 5
XBP1 X-box binding protein 1