BRD-K88707333_NCGC00182378-01_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K88707333_NCGC00182378-01_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM69A family with sequence similarity 69, member A
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPX2 glutathione peroxidase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MMP2 matrix metallopeptidase 2
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
ORC1 origin recognition complex, subunit 1
PAPD7 PAP associated domain containing 7
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TBX3 T-box 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
WBP5 WW domain binding protein 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATXN1 ataxin 1
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CHL1 cell adhesion molecule L1-like
CST7 cystatin F (leukocystatin)
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
FLG filaggrin
FXYD2 FXYD domain containing ion transport regulator 2
GRWD1 glutamate-rich WD repeat containing 1
HOXA5 homeobox A5
HOXC6 homeobox C6
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
LAMB1 laminin, beta 1
LDHB lactate dehydrogenase B
MGP matrix Gla protein
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCB protein kinase C, beta
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TSPYL5 TSPY-like 5
VCAN versican
ZNF185 zinc finger protein 185 (LIM domain)