BRD-K88707333_NCGC00182378-01_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K88707333_NCGC00182378-01_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
BAG3 BCL2-associated athanogene 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSL cathepsin L
CTSZ cathepsin Z
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITM2A integral membrane protein 2A
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NRCAM neuronal cell adhesion molecule
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TOX thymocyte selection-associated high mobility group box
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CCND1 cyclin D1
CST1 cystatin SN
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DYNLT3 dynein, light chain, Tctex-type 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GLS glutaminase
HOPX HOP homeobox
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
MOK MOK protein kinase
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRIP1 nuclear receptor interacting protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
SMAD3 SMAD family member 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2