BRD-K88677950_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K88677950_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CARS cysteinyl-tRNA synthetase
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CELF2 CUGBP, Elav-like family member 2
CERS6 ceramide synthase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HYOU1 hypoxia up-regulated 1
KRT23 keratin 23, type I
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF5 activating transcription factor 5
CDC25A cell division cycle 25A
CHL1 cell adhesion molecule L1-like
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPH1 heat shock 105kDa/110kDa protein 1
LAMC2 laminin, gamma 2
LDHB lactate dehydrogenase B
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCOLN1 mucolipin 1
MFSD10 major facilitator superfamily domain containing 10
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PCDH9 protocadherin 9
PPIF peptidylprolyl isomerase F
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TOR1A torsin family 1, member A (torsin A)
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B