BRD-K88677950_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K88677950_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
ASMTL acetylserotonin O-methyltransferase-like
BLVRB biliverdin reductase B
CAST calpastatin
CBS cystathionine-beta-synthase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHMP4A charged multivesicular body protein 4A
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGA fibrinogen alpha chain
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
GC group-specific component (vitamin D binding protein)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HP haptoglobin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LYPD1 LY6/PLAUR domain containing 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYO10 myosin X
NME4 NME/NM23 nucleoside diphosphate kinase 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIDT2 SID1 transmembrane family, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TF transferrin
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ATP11B ATPase, class VI, type 11B
CD24 CD24 molecule
CLDND1 claudin domain containing 1
CORO1A coronin, actin binding protein, 1A
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
HES1 hes family bHLH transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LINC00341 long intergenic non-protein coding RNA 341
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
METTL3 methyltransferase like 3
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
NBPF10 neuroblastoma breakpoint family, member 10
NFIB nuclear factor I/B
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
VCAN versican
VNN1 vanin 1