BRD-K88677950_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K88677950_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
DDIT4 DNA-damage-inducible transcript 4
EAPP E2F-associated phosphoprotein
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS1 regulator of G-protein signaling 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC6 structural maintenance of chromosomes 6
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ADIPOR2 adiponectin receptor 2
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CDC25A cell division cycle 25A
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NOP2 NOP2 nucleolar protein
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SPRY4 sprouty homolog 4 (Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TSC22D2 TSC22 domain family, member 2
TUBB4B tubulin, beta 4B class IVb