BRD-K88625236_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K88625236_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP6 charged multivesicular body protein 6
COL5A1 collagen, type V, alpha 1
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
DPEP1 dipeptidase 1 (renal)
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBP1 fructose-1,6-bisphosphatase 1
FKBP14 FK506 binding protein 14, 22 kDa
FMO1 flavin containing monooxygenase 1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOMER3 homer scaffolding protein 3
HOPX HOP homeobox
HOXB6 homeobox B6
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
ISOC1 isochorismatase domain containing 1
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LPL lipoprotein lipase
MBOAT7 membrane bound O-acyltransferase domain containing 7
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NGRN neugrin, neurite outgrowth associated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PMP2 peripheral myelin protein 2
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RABGAP1L RAB GTPase activating protein 1-like
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY2 sprouty homolog 2 (Drosophila)
TCL1A T-cell leukemia/lymphoma 1A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
UPP1 uridine phosphorylase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB38 zinc finger and BTB domain containing 38
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAN aggrecan
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA7 annexin A7
C1S complement component 1, s subcomponent
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDCA8 cell division cycle associated 8
CFB complement factor B
CLU clusterin
DPT dermatopontin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FBXO9 F-box protein 9
FHL1 four and a half LIM domains 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HIST3H2A histone cluster 3, H2a
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXC6 homeobox C6
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0907 KIAA0907
LPAR6 lysophosphatidic acid receptor 6
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAVS mitochondrial antiviral signaling protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PID1 phosphotyrosine interaction domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPAP2B phosphatidic acid phosphatase type 2B
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRM protein tyrosine phosphatase, receptor type, M
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SORBS2 sorbin and SH3 domain containing 2
SYNGR1 synaptogyrin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
WNT5A wingless-type MMTV integration site family, member 5A