BRD-K88573743_A443654_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K88573743_A443654_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANK2 ankyrin 2, neuronal
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALML5 calmodulin-like 5
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD9 CD9 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDSN corneodesmosin
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DSC1 desmocollin 1
DSG1 desmoglein 1
EFNB2 ephrin-B2
EMP3 epithelial membrane protein 3
FGFR2 fibroblast growth factor receptor 2
FLG filaggrin
FOXO4 forkhead box O4
H2BFS H2B histone family, member S (pseudogene)
HAL histidine ammonia-lyase
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HOPX HOP homeobox
KAT6B K(lysine) acetyltransferase 6B
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
LBH limb bud and heart development
LCE2B late cornified envelope 2B
LOR loricrin
LYST lysosomal trafficking regulator
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NOV nephroblastoma overexpressed
NPTX2 neuronal pentraxin II
P3H2 prolyl 3-hydroxylase 2
PLIN2 perilipin 2
PRPF4 pre-mRNA processing factor 4
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RBM6 RNA binding motif protein 6
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPEN spen family transcriptional repressor
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TBL1X transducin (beta)-like 1X-linked
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
TPSB2 tryptase beta 2 (gene/pseudogene)
TUFT1 tuftelin 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
BMP7 bone morphogenetic protein 7
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
CALU calumenin
CCDC86 coiled-coil domain containing 86
CCND3 cyclin D3
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD34 CD34 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CIRBP cold inducible RNA binding protein
COL5A1 collagen, type V, alpha 1
COPS8 COP9 signalosome subunit 8
CRELD2 cysteine-rich with EGF-like domains 2
CRNN cornulin
CXCL12 chemokine (C-X-C motif) ligand 12
DHCR24 24-dehydrocholesterol reductase
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ERMP1 endoplasmic reticulum metallopeptidase 1
FABP4 fatty acid binding protein 4, adipocyte
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FASN fatty acid synthase
GALE UDP-galactose-4-epimerase
GCLM glutamate-cysteine ligase, modifier subunit
GPX3 glutathione peroxidase 3
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
ITGB5 integrin, beta 5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
MAL mal, T-cell differentiation protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MREG melanoregulin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITX1 paired-like homeodomain 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSIP1 PC4 and SFRS1 interacting protein 1
PXDN peroxidasin
RER1 retention in endoplasmic reticulum sorting receptor 1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SELL selectin L
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR3 small proline-rich protein 3
SRPX sushi-repeat containing protein, X-linked
SRPX2 sushi-repeat containing protein, X-linked 2
SRSF6 serine/arginine-rich splicing factor 6
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TSPAN4 tetraspanin 4
UBE3C ubiquitin protein ligase E3C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZC3HAV1 zinc finger CCCH-type, antiviral 1