BRD-K88573743_A443654_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

375 genes differentially expressed following the BRD-K88573743_A443654_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF4 activating transcription factor 4
BBX bobby sox homolog (Drosophila)
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
C21ORF91 chromosome 21 open reading frame 91
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC3B C-type lectin domain family 3, member B
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRTC3 CREB regulated transcription coactivator 3
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP7 dual specificity phosphatase 7
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF4 E74-like factor 4 (ets domain transcription factor)
EXOSC4 exosome component 4
FAM131A family with sequence similarity 131, member A
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT3 fms-related tyrosine kinase 3
FNTA farnesyltransferase, CAAX box, alpha
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBEGF heparin-binding EGF-like growth factor
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IL6R interleukin 6 receptor
IST1 increased sodium tolerance 1 homolog (yeast)
ITGA7 integrin, alpha 7
JUND jun D proto-oncogene
KDSR 3-ketodihydrosphingosine reductase
KIAA0125 KIAA0125
KIAA0907 KIAA0907
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIN37 lin-37 DREAM MuvB core complex component
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAX MYC associated factor X
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NISCH nischarin
NOTCH3 notch 3
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
OLFML2A olfactomedin-like 2A
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHF20 PHD finger protein 20
PHGDH phosphoglycerate dehydrogenase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLSCR4 phospholipid scramblase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PROS1 protein S (alpha)
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QKI QKI, KH domain containing, RNA binding
RAB33B RAB33B, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM22 RNA binding motif protein 22
RBM39 RNA binding motif protein 39
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS5 regulator of G-protein signaling 5
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
RYBP RING1 and YY1 binding protein
SAR1A secretion associated, Ras related GTPase 1A
SCAND1 SCAN domain containing 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIRT1 sirtuin 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SMAD7 SMAD family member 7
SNX6 sorting nexin 6
SORBS1 sorbin and SH3 domain containing 1
SPATA2L spermatogenesis associated 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
SST somatostatin
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
SYBU syntabulin (syntaxin-interacting)
TCF4 transcription factor 4
TES testin LIM domain protein
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRAM1 translocation associated membrane protein 1
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
USP36 ubiquitin specific peptidase 36
WDR47 WD repeat domain 47
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YY1 YY1 transcription factor
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF131 zinc finger protein 131
ZNF410 zinc finger protein 410

decreased expression

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ACTG2 actin, gamma 2, smooth muscle, enteric
AIDA axin interactor, dorsalization associated
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATF5 activating transcription factor 5
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
B9D1 B9 protein domain 1
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML3 calmodulin-like 3
CALR calreticulin
CANX calnexin
CBX1 chromobox homolog 1
CCNF cyclin F
CD24 CD24 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEP70 centrosomal protein 70kDa
CETN3 centrin, EF-hand protein, 3
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIRBP cold inducible RNA binding protein
CIT citron rho-interacting serine/threonine kinase
CKAP4 cytoskeleton-associated protein 4
CLDN3 claudin 3
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
COMT catechol-O-methyltransferase
COTL1 coactosin-like F-actin binding protein 1
CTGF connective tissue growth factor
CTSB cathepsin B
CYB5R2 cytochrome b5 reductase 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCTD dCMP deaminase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
DZIP3 DAZ interacting zinc finger protein 3
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELF5 E74-like factor 5 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENSA endosulfine alpha
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
FOCAD focadhesin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDE1 glycerophosphodiester phosphodiesterase 1
GTF2A2 general transcription factor IIA, 2, 12kDa
GYG1 glycogenin 1
HAS2 hyaluronan synthase 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
IGSF3 immunoglobulin superfamily, member 3
INTS3 integrator complex subunit 3
ITGA6 integrin, alpha 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF20A kinesin family member 20A
KPNB1 karyopherin (importin) beta 1
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LPXN leupaxin
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCFD2 multiple coagulation factor deficiency 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MTCH2 mitochondrial carrier 2
MTSS1 metastasis suppressor 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NEBL nebulette
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCM1 pericentriolar material 1
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRAME preferentially expressed antigen in melanoma
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAB4A RAB4A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1GAP RAP1 GTPase activating protein
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RMDN1 regulator of microtubule dynamics 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCCPDH saccharopine dehydrogenase (putative)
SDC1 syndecan 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPA17 sperm autoantigenic protein 17
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D5 TBC1 domain family, member 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TGFBI transforming growth factor, beta-induced, 68kDa
THYN1 thymocyte nuclear protein 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TRIM14 tripartite motif containing 14
TRIOBP TRIO and F-actin binding protein
TRMT5 tRNA methyltransferase 5
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USP18 ubiquitin specific peptidase 18
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A
ZNF185 zinc finger protein 185 (LIM domain)