BRD-K88573743_A443654_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K88573743_A443654_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ASPN asporin
ASRGL1 asparaginase like 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK14 cyclin-dependent kinase 14
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
COL6A2 collagen, type VI, alpha 2
CSTA cystatin A (stefin A)
DIRAS3 DIRAS family, GTP-binding RAS-like 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
GPX1 glutathione peroxidase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LGALS3 lectin, galactoside-binding, soluble, 3
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAWR PRKC, apoptosis, WT1, regulator
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAGL1 pleiomorphic adenoma gene-like 1
PSPH phosphoserine phosphatase
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TMEM47 transmembrane protein 47
TPGS2 tubulin polyglutamylase complex subunit 2
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
CALCA calcitonin-related polypeptide alpha
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HAUS3 HAUS augmin-like complex, subunit 3
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA1 homeobox A1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
ISG20 interferon stimulated exonuclease gene 20kDa
JADE2 jade family PHD finger 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LPIN1 lipin 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MMP12 matrix metallopeptidase 12
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SCGB2A2 secretoglobin, family 2A, member 2
SECISBP2L SECIS binding protein 2-like
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STX3 syntaxin 3
TARP TCR gamma alternate reading frame protein
TBP TATA box binding protein
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
WTAP Wilms tumor 1 associated protein