BRD-K88573743_A443654_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K88573743_A443654_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOC aldolase C, fructose-bisphosphate
AMPH amphiphysin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
CETN2 centrin, EF-hand protein, 2
CHERP calcium homeostasis endoplasmic reticulum protein
CLDN10 claudin 10
CXORF57 chromosome X open reading frame 57
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM110B family with sequence similarity 110, member B
FBXL12 F-box and leucine-rich repeat protein 12
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMGN5 high mobility group nucleosome binding domain 5
IL1RN interleukin 1 receptor antagonist
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPT microtubule-associated protein tau
MMP3 matrix metallopeptidase 3
MN1 meningioma (disrupted in balanced translocation) 1
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NACA nascent polypeptide-associated complex alpha subunit
NEFL neurofilament, light polypeptide
NID1 nidogen 1
NKX2-2 NK2 homeobox 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM2 PR domain containing 2, with ZNF domain
PRELP proline/arginine-rich end leucine-rich repeat protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RNMT RNA (guanine-7-) methyltransferase
RPL37A ribosomal protein L37a
RSL1D1 ribosomal L1 domain containing 1
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SSPN sarcospan
SSR4 signal sequence receptor, delta
STC2 stanniocalcin 2
SULF1 sulfatase 1
TUBB2A tubulin, beta 2A class IIa
USPL1 ubiquitin specific peptidase like 1
VWF von Willebrand factor
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLMH bleomycin hydrolase
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C4ORF27 chromosome 4 open reading frame 27
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNA2 cyclin A2
CCNB2 cyclin B2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CLCN3 chloride channel, voltage-sensitive 3
COTL1 coactosin-like F-actin binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
ELAVL1 ELAV like RNA binding protein 1
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSTA4 glutathione S-transferase alpha 4
GTF2A2 general transcription factor IIA, 2, 12kDa
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LBR lamin B receptor
MAB21L2 mab-21-like 2 (C. elegans)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MYO10 myosin X
NEK7 NIMA-related kinase 7
NUP37 nucleoporin 37kDa
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PAPOLA poly(A) polymerase alpha
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS13 regulator of G-protein signaling 13
RPS11 ribosomal protein S11
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAGP small cell adhesion glycoprotein
SPP1 secreted phosphoprotein 1
TBC1D4 TBC1 domain family, member 4
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDTC1 WD and tetratricopeptide repeats 1
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1