BRD-K88573743_A443654_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K88573743_A443654_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8 A kinase (PRKA) anchor protein 8
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOE apolipoprotein E
AREG amphiregulin
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BEX1 brain expressed, X-linked 1
CA11 carbonic anhydrase XI
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CS citrate synthase
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM63A family with sequence similarity 63, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
LDHB lactate dehydrogenase B
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MTMR11 myotubularin related protein 11
MXRA7 matrix-remodelling associated 7
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAM peptidylglycine alpha-amidating monooxygenase
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
RTN1 reticulon 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SPRY2 sprouty homolog 2 (Drosophila)
SSR4 signal sequence receptor, delta
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMOD1 tropomodulin 1
TSPAN7 tetraspanin 7
VCAN versican
WLS wntless Wnt ligand secretion mediator
WT1 Wilms tumor 1
ZBTB10 zinc finger and BTB domain containing 10
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ARMCX2 armadillo repeat containing, X-linked 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRCA1 breast cancer 1, early onset
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CLIC3 chloride intracellular channel 3
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
GTF2A2 general transcription factor IIA, 2, 12kDa
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LTF lactotransferrin
LUM lumican
MB myoglobin
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODC1 ornithine decarboxylase 1
PCNA proliferating cell nuclear antigen
PKP1 plakophilin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
S100P S100 calcium binding protein P
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SRSF7 serine/arginine-rich splicing factor 7
TFRC transferrin receptor
TMPO thymopoietin
TRAK2 trafficking protein, kinesin binding 2
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1
YME1L1 YME1-like 1 ATPase
ZDHHC6 zinc finger, DHHC-type containing 6
ZWILCH zwilch kinetochore protein