BRD-K88573743_A443654_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K88573743_A443654_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY1 adenylate cyclase 1 (brain)
ADCY9 adenylate cyclase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARID1A AT rich interactive domain 1A (SWI-like)
ASPN asporin
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BIRC2 baculoviral IAP repeat containing 2
CAMLG calcium modulating ligand
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP1B charged multivesicular body protein 1B
COL15A1 collagen, type XV, alpha 1
CRY1 cryptochrome circadian clock 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL8 chemokine (C-X-C motif) ligand 8
DYNLT3 dynein, light chain, Tctex-type 3
ESR1 estrogen receptor 1
FAM53C family with sequence similarity 53, member C
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT3 fms-related tyrosine kinase 3
FNBP4 formin binding protein 4
FOXJ3 forkhead box J3
GAB2 GRB2-associated binding protein 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAS1 growth arrest-specific 1
GOLGA8H golgin A8 family, member H
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
ITGA7 integrin, alpha 7
JMJD1C jumonji domain containing 1C
KDM4B lysine (K)-specific demethylase 4B
KRT23 keratin 23, type I
LIN37 lin-37 DREAM MuvB core complex component
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC283683 uncharacterized LOC283683
LONP2 lon peptidase 2, peroxisomal
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
METTL7A methyltransferase like 7A
MEX3C mex-3 RNA binding family member C
MICB MHC class I polypeptide-related sequence B
MPPED2 metallophosphoesterase domain containing 2
MSX1 msh homeobox 1
MTDH metadherin
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
NBPF10 neuroblastoma breakpoint family, member 10
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NISCH nischarin
NONO non-POU domain containing, octamer-binding
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
OPN3 opsin 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP2 poly (ADP-ribose) polymerase 2
PCGF2 polycomb group ring finger 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRL platelet-derived growth factor receptor-like
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PHF20 PHD finger protein 20
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G15 phospholipase A2, group XV
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
RBP1 retinol binding protein 1, cellular
RNF144A ring finger protein 144A
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SNN stannin
SNX10 sorting nexin 10
SNX6 sorting nexin 6
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SPEN spen family transcriptional repressor
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
SUSD6 sushi domain containing 6
TCF4 transcription factor 4
TMOD1 tropomodulin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOR1AIP1 torsin A interacting protein 1
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
WIPF2 WAS/WASL interacting protein family, member 2
WT1 Wilms tumor 1
XYLT1 xylosyltransferase I
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRL2 adhesion G protein-coupled receptor L2
AEBP1 AE binding protein 1
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA4 annexin A4
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
B3GNT1
BAG2 BCL2-associated athanogene 2
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C7 complement component 7
CADM1 cell adhesion molecule 1
CAST calpastatin
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXF1 forkhead box F1
GALE UDP-galactose-4-epimerase
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
GSE1 Gse1 coiled-coil protein
GTF2A2 general transcription factor IIA, 2, 12kDa
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HMBS hydroxymethylbilane synthase
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KRT20 keratin 20, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL1 lysyl oxidase-like 1
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
LUM lumican
LXN latexin
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MATN2 matrilin 2
MCFD2 multiple coagulation factor deficiency 2
MSMB microseminoprotein, beta-
MYCBP MYC binding protein
MYLK myosin light chain kinase
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIT2 nitrilase family, member 2
NMI N-myc (and STAT) interactor
NRP1 neuropilin 1
NUP37 nucleoporin 37kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFDN4 prefoldin subunit 4
PLBD1 phospholipase B domain containing 1
PPA2 pyrophosphatase (inorganic) 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRMT1 protein arginine methyltransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVRL3 poliovirus receptor-related 3
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RALB v-ral simian leukemia viral oncogene homolog B
RAP1GAP RAP1 GTPase activating protein
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASL12 RAS-like, family 12
S100P S100 calcium binding protein P
SDC4 syndecan 4
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPC surfactant protein C
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SNX7 sorting nexin 7
SORD sorbitol dehydrogenase
SOSTDC1 sclerostin domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STAMBP STAM binding protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TARP TCR gamma alternate reading frame protein
TCF21 transcription factor 21
TPMT thiopurine S-methyltransferase
WDR61 WD repeat domain 61
WWC2 WW and C2 domain containing 2