BRD-K88573743_A443654_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K88573743_A443654_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASRGL1 asparaginase like 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CYFIP2 cytoplasmic FMR1 interacting protein 2
EPCAM epithelial cell adhesion molecule
F13A1 coagulation factor XIII, A1 polypeptide
FGF9 fibroblast growth factor 9
FZD6 frizzled class receptor 6
GPC4 glypican 4
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KIAA0226L KIAA0226-like
KRT8 keratin 8, type II
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC16A leucine rich repeat containing 16A
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL7A methyltransferase like 7A
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLCB4 phospholipase C, beta 4
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
QPRT quinolinate phosphoribosyltransferase
RNF130 ring finger protein 130
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3YL1 SH3 and SYLF domain containing 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM5 transmembrane protein 5
TNS3 tensin 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VGLL1 vestigial-like family member 1
VWA5A von Willebrand factor A domain containing 5A
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CST7 cystatin F (leukocystatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR2 early growth response 2
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL6 interleukin 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LIF leukemia inhibitory factor
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEFM neurofilament, medium polypeptide
NFE2 nuclear factor, erythroid 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
S100A12 S100 calcium binding protein A12
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUFT1 tuftelin 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZYX zyxin