BRD-K88573743_A443654_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K88573743_A443654_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ARG2 arginase 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C3 complement component 3
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CMC4 C-x(9)-C motif containing 4
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
GATA2 GATA binding protein 2
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HP haptoglobin
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
KRT15 keratin 15, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
OLFM4 olfactomedin 4
OXTR oxytocin receptor
PDGFC platelet derived growth factor C
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCB protein kinase C, beta
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RBP1 retinol binding protein 1, cellular
SCGB2A2 secretoglobin, family 2A, member 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN6 tetraspanin 6
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGTR1 angiotensin II receptor, type 1
AK1 adenylate kinase 1
AXIN1 axin 1
BASP1 brain abundant, membrane attached signal protein 1
CD36 CD36 molecule (thrombospondin receptor)
CPM carboxypeptidase M
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
EFS embryonal Fyn-associated substrate
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GREB1 growth regulation by estrogen in breast cancer 1
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LAMC2 laminin, gamma 2
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MGLL monoglyceride lipase
NDRG1 N-myc downstream regulated 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SEC11A SEC11 homolog A (S. cerevisiae)
SNAP25 synaptosomal-associated protein, 25kDa
SNX11 sorting nexin 11
SRI sorcin
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
UGDH UDP-glucose 6-dehydrogenase