BRD-K88573743_A443654_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K88573743_A443654_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALB albumin
ANO1 anoctamin 1, calcium activated chloride channel
ARL4C ADP-ribosylation factor-like 4C
ASRGL1 asparaginase like 1
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CERS6 ceramide synthase 6
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
FGF9 fibroblast growth factor 9
GRB10 growth factor receptor-bound protein 10
GRN granulin
HBB hemoglobin, beta
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
KRT23 keratin 23, type I
KYNU kynureninase
LBH limb bud and heart development
MAP1B microtubule-associated protein 1B
MMP1 matrix metallopeptidase 1
MSX1 msh homeobox 1
MTF2 metal response element binding transcription factor 2
MUC16 mucin 16, cell surface associated
NAV2 neuron navigator 2
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKTR natural killer cell triggering receptor
NOV nephroblastoma overexpressed
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PILRB paired immunoglobin-like type 2 receptor beta
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIG peptidylprolyl isomerase G (cyclophilin G)
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PTCH1 patched 1
PTPRO protein tyrosine phosphatase, receptor type, O
RPIA ribose 5-phosphate isomerase A
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX4 SRY (sex determining region Y)-box 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38L serine/threonine kinase 38 like
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM63A transmembrane protein 63A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBED1 zinc finger, BED-type containing 1
ZNF266 zinc finger protein 266
ZNF91 zinc finger protein 91
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
ALDOC aldolase C, fructose-bisphosphate
ATF5 activating transcription factor 5
B3GNT1
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CALR calreticulin
CIRBP cold inducible RNA binding protein
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EDNRB endothelin receptor type B
EIF5 eukaryotic translation initiation factor 5
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GALE UDP-galactose-4-epimerase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREB1 growth regulation by estrogen in breast cancer 1
GSTT1 glutathione S-transferase theta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP7 microtubule-associated protein 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLF1 myeloid leukemia factor 1
MOXD1 monooxygenase, DBH-like 1
MSMO1 methylsterol monooxygenase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMI N-myc (and STAT) interactor
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGES prostaglandin E synthase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD23B RAD23 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SCARB1 scavenger receptor class B, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A4 solute carrier family 16, member 4
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STAP1 signal transducing adaptor family member 1
TCF21 transcription factor 21
TMEM135 transmembrane protein 135
TOX3 TOX high mobility group box family member 3
TPST1 tyrosylprotein sulfotransferase 1
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UQCRC2 ubiquinol-cytochrome c reductase core protein II
WDR61 WD repeat domain 61
YME1L1 YME1-like 1 ATPase