BRD-K88573743_A443654_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K88573743_A443654_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AREG amphiregulin
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASXL1 additional sex combs like transcriptional regulator 1
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BCL6 B-cell CLL/lymphoma 6
BTG3 BTG family, member 3
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP1B charged multivesicular body protein 1B
CLCA2 chloride channel accessory 2
COL11A1 collagen, type XI, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLX5 distal-less homeobox 5
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FNTA farnesyltransferase, CAAX box, alpha
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GAB2 GRB2-associated binding protein 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GPC1 glypican 1
HBEGF heparin-binding EGF-like growth factor
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
IGFBP7 insulin-like growth factor binding protein 7
INPP1 inositol polyphosphate-1-phosphatase
KIAA0907 KIAA0907
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LIMA1 LIM domain and actin binding 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAST2 microtubule associated serine/threonine kinase 2
MED17 mediator complex subunit 17
MIR22HG MIR22 host gene
MITF microphthalmia-associated transcription factor
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO6 myosin VI
NT5E 5'-nucleotidase, ecto (CD73)
NUPL1 nucleoporin like 1
PBX3 pre-B-cell leukemia homeobox 3
PCGF2 polycomb group ring finger 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G15 phospholipase A2, group XV
PTHLH parathyroid hormone-like hormone
RAB38 RAB38, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RRAGC Ras-related GTP binding C
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1B small proline-rich protein 1B
STK17A serine/threonine kinase 17a
STX3 syntaxin 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TKTL1 transketolase-like 1
TOB1 transducer of ERBB2, 1
TRAF3IP2 TRAF3 interacting protein 2
TRAK1 trafficking protein, kinesin binding 1
TUFT1 tuftelin 1
WEE1 WEE1 G2 checkpoint kinase
ZBTB18 zinc finger and BTB domain containing 18
ZNF274 zinc finger protein 274
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
ASS1 argininosuccinate synthase 1
B9D1 B9 protein domain 1
C7 complement component 7
CADPS2 Ca++-dependent secretion activator 2
CALCA calcitonin-related polypeptide alpha
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CETN3 centrin, EF-hand protein, 3
CHMP4A charged multivesicular body protein 4A
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DCTD dCMP deaminase
DHCR24 24-dehydrocholesterol reductase
DLD dihydrolipoamide dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EDNRA endothelin receptor type A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHX2 epoxide hydrolase 2, cytoplasmic
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLDC glycine dehydrogenase (decarboxylating)
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI35 interferon-induced protein 35
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IQGAP2 IQ motif containing GTPase activating protein 2
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
LAP3 leucine aminopeptidase 3
LCN2 lipocalin 2
LEPR leptin receptor
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCM5 minichromosome maintenance complex component 5
MPC1 mitochondrial pyruvate carrier 1
MTCH2 mitochondrial carrier 2
NBN nibrin
NEFH neurofilament, heavy polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PAH phenylalanine hydroxylase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PCP4 Purkinje cell protein 4
PGD phosphogluconate dehydrogenase
PPA2 pyrophosphatase (inorganic) 2
PRDX2 peroxiredoxin 2
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RELN reelin
SCCPDH saccharopine dehydrogenase (putative)
SELENBP1 selenium binding protein 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TF transferrin
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN6 tetraspanin 6
TSPYL5 TSPY-like 5
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP18 ubiquitin specific peptidase 18
VCAN versican
WDR61 WD repeat domain 61
ZIC1 Zic family member 1