BRD-K88573743_A443654_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

329 genes differentially expressed following the BRD-K88573743_A443654_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AKAP8L A kinase (PRKA) anchor protein 8-like
APOC2 apolipoprotein C-II
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX1 armadillo repeat containing, X-linked 1
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
C6ORF48 chromosome 6 open reading frame 48
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD37 CD37 molecule
CD9 CD9 molecule
CFB complement factor B
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP1B charged multivesicular body protein 1B
CLC Charcot-Leyden crystal galectin
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DENND1A DENN/MADD domain containing 1A
DIO1 deiodinase, iodothyronine, type I
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ELF4 E74-like factor 4 (ets domain transcription factor)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAM110B family with sequence similarity 110, member B
FAM46A family with sequence similarity 46, member A
FBN2 fibrillin 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEM1C fem-1 homolog c (C. elegans)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS2 fibroblast growth factor receptor substrate 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOLGA8H golgin A8 family, member H
GPR183 G protein-coupled receptor 183
GRB10 growth factor receptor-bound protein 10
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HHEX hematopoietically expressed homeobox
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
IL1RN interleukin 1 receptor antagonist
INSM1 insulinoma-associated 1
ITGA7 integrin, alpha 7
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM2 junctional adhesion molecule 2
JMJD1C jumonji domain containing 1C
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM5A lysine (K)-specific demethylase 5A
KDM6A lysine (K)-specific demethylase 6A
KLHL21 kelch-like family member 21
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LOC283683 uncharacterized LOC283683
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2 microtubule-associated protein 2
MAPK6 mitogen-activated protein kinase 6
MAST2 microtubule associated serine/threonine kinase 2
MAU2 MAU2 sister chromatid cohesion factor
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NEU1 sialidase 1 (lysosomal sialidase)
NISCH nischarin
NKG7 natural killer cell granule protein 7
NKTR natural killer cell triggering receptor
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OLFML2A olfactomedin-like 2A
PBX3 pre-B-cell leukemia homeobox 3
PCBP2 poly(rC) binding protein 2
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PER3 period circadian clock 3
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLXNC1 plexin C1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RAB33A RAB33A, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RAP2C RAP2C, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
RLF rearranged L-myc fusion
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE6 ribonuclease, RNase A family, k6
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
RSBN1 round spermatid basic protein 1
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SDC2 syndecan 2
SEC24A SEC24 family member A
SEPT4 septin 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SPATA20 spermatogenesis associated 20
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
SRSF6 serine/arginine-rich splicing factor 6
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBD thrombomodulin
TLE3 transducin-like enhancer of split 3
TMEM255A transmembrane protein 255A
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UBL3 ubiquitin-like 3
UFM1 ubiquitin-fold modifier 1
USP36 ubiquitin specific peptidase 36
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WIPF2 WAS/WASL interacting protein family, member 2
XIST X inactive specific transcript (non-protein coding)
ZBTB43 zinc finger and BTB domain containing 43
ZFYVE26 zinc finger, FYVE domain containing 26
ZHX2 zinc fingers and homeoboxes 2
ZNF136 zinc finger protein 136
ZNF222 zinc finger protein 222
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274
ZNF394 zinc finger protein 394
ZNF410 zinc finger protein 410
ZNF430 zinc finger protein 430
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BICC1 BicC family RNA binding protein 1
BIRC5 baculoviral IAP repeat containing 5
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C21ORF59 chromosome 21 open reading frame 59
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5R2 cytochrome b5 reductase 2
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DYNLT1 dynein, light chain, Tctex-type 1
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FH fumarate hydratase
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GTF2A2 general transcription factor IIA, 2, 12kDa
HMGN1 high mobility group nucleosome binding domain 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFT57 intraflagellar transport 57
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LOXL2 lysyl oxidase-like 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MKI67 marker of proliferation Ki-67
MORC4 MORC family CW-type zinc finger 4
MSH2 mutS homolog 2
MYH10 myosin, heavy chain 10, non-muscle
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NUP37 nucleoporin 37kDa
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PKP4 plakophilin 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PON3 paraoxonase 3
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIE peptidylprolyl isomerase E (cyclophilin E)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTRF polymerase I and transcript release factor
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SCCPDH saccharopine dehydrogenase (putative)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAGP small cell adhesion glycoprotein
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPA17 sperm autoantigenic protein 17
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFDP1 transcription factor Dp-1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR61 WD repeat domain 61
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)