BRD-K88573743_A443654_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K88573743_A443654_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ANKRD10 ankyrin repeat domain 10
BEX1 brain expressed, X-linked 1
CALB1 calbindin 1, 28kDa
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
FOXO4 forkhead box O4
FRZB frizzled-related protein
GLA galactosidase, alpha
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM5D lysine (K)-specific demethylase 5D
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
NASP nuclear autoantigenic sperm protein (histone-binding)
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD7 SMAD family member 7
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SYNJ2 synaptojanin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM50A transmembrane protein 50A
TRAF5 TNF receptor-associated factor 5
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEZF1 vascular endothelial zinc finger 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRG6 adhesion G protein-coupled receptor G6
AIM2 absent in melanoma 2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BAG2 BCL2-associated athanogene 2
BIN1 bridging integrator 1
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD14 CD14 molecule
CD24 CD24 molecule
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLIC3 chloride intracellular channel 3
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CSTA cystatin A (stefin A)
CTSC cathepsin C
CTSZ cathepsin Z
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FKBP10 FK506 binding protein 10, 65 kDa
FOXC1 forkhead box C1
GALE UDP-galactose-4-epimerase
GOLM1 golgi membrane protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HSPB1 heat shock 27kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
KIAA1598
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MATN2 matrilin 2
MB myoglobin
MGP matrix Gla protein
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NEB nebulin
NFIB nuclear factor I/B
NR2F6 nuclear receptor subfamily 2, group F, member 6
NXN nucleoredoxin
OAT ornithine aminotransferase
PDLIM7 PDZ and LIM domain 7 (enigma)
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PITX1 paired-like homeodomain 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLS3 plastin 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
REEP5 receptor accessory protein 5
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SKAP2 src kinase associated phosphoprotein 2
SNX10 sorting nexin 10
SOBP sine oculis binding protein homolog (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
SVIL supervillin
SYNM synemin, intermediate filament protein
TGFA transforming growth factor, alpha
TMEM45A transmembrane protein 45A
TNNC1 troponin C type 1 (slow)
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TYMP thymidine phosphorylase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
WSB2 WD repeat and SOCS box containing 2
YAP1 Yes-associated protein 1