BRD-K88568253_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K88568253_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK4 cyclin-dependent kinase 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CPB1 carboxypeptidase B1 (tissue)
CXADR coxsackie virus and adenovirus receptor
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCN decorin
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
EAF2 ELL associated factor 2
ENOPH1 enolase-phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FST follistatin
HOXD1 homeobox D1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6R interleukin 6 receptor
IQGAP1 IQ motif containing GTPase activating protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MME membrane metallo-endopeptidase
MTA1 metastasis associated 1
MYO1B myosin IB
MYO6 myosin VI
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PEG10 paternally expressed 10
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRR7 proline rich 7 (synaptic)
RGCC regulator of cell cycle
RPS5 ribosomal protein S5
S100A10 S100 calcium binding protein A10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPT11 septin 11
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SRP72 signal recognition particle 72kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TUBB2B tubulin, beta 2B class IIb
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF281 zinc finger protein 281
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CLSTN1 calsyntenin 1
COL16A1 collagen, type XVI, alpha 1
COL7A1 collagen, type VII, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
F3 coagulation factor III (thromboplastin, tissue factor)
FMOD fibromodulin
GALC galactosylceramidase
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPB8 heat shock 22kDa protein 8
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
OPN3 opsin 3
PFKP phosphofructokinase, platelet
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PMEPA1 prostate transmembrane protein, androgen induced 1
PROM1 prominin 1
RNF167 ring finger protein 167
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SCG5 secretogranin V
SDC2 syndecan 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE4 transducin-like enhancer of split 4
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZEB2 zinc finger E-box binding homeobox 2