BRD-K88510285_B675700.cdx_VCAP_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-K88510285_B675700.cdx_VCAP_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
C1QB complement component 1, q subcomponent, B chain
CARS cysteinyl-tRNA synthetase
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CD4 CD4 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EIF1 eukaryotic translation initiation factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EPRS glutamyl-prolyl-tRNA synthetase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
GABARAPL1 GABA(A) receptor-associated protein like 1
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL2RG interleukin 2 receptor, gamma
INHBA inhibin, beta A
IQCG IQ motif containing G
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0368 KIAA0368
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFM neurofilament, medium polypeptide
NELL2 NEL-like 2 (chicken)
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM4 PDZ and LIM domain 4
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSME4 proteasome (prosome, macropain) activator subunit 4
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
TAC1 tachykinin, precursor 1
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TM6SF1 transmembrane 6 superfamily member 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNL1 thioredoxin-like 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UFD1L ubiquitin fusion degradation 1 like (yeast)
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WFS1 Wolfram syndrome 1 (wolframin)
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
ADA adenosine deaminase
ADCY1 adenylate cyclase 1 (brain)
AIM1 absent in melanoma 1
AKAP1 A kinase (PRKA) anchor protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARF3 ADP-ribosylation factor 3
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
B3GNT1
BST2 bone marrow stromal cell antigen 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD9 CD9 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLIC3 chloride intracellular channel 3
COX17 COX17 cytochrome c oxidase copper chaperone
CRIP1 cysteine-rich protein 1 (intestinal)
DHFR dihydrofolate reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENDOD1 endonuclease domain containing 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERLIN2 ER lipid raft associated 2
FAS Fas cell surface death receptor
FGG fibrinogen gamma chain
FLNB filamin B, beta
FSTL1 follistatin-like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLM1 golgi membrane protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
MARCKSL1 MARCKS-like 1
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MSL1 male-specific lethal 1 homolog (Drosophila)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NFIB nuclear factor I/B
NPY neuropeptide Y
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTGIS prostaglandin I2 (prostacyclin) synthase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
TYRP1 tyrosinase-related protein 1
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP18 ubiquitin specific peptidase 18
VCAN versican
VIM vimentin