BRD-K88510285_B675700.cdx_VCAP_24.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

374 genes differentially expressed following the BRD-K88510285_B675700.cdx_VCAP_24.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ANXA2 annexin A2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASPN asporin
ATF3 activating transcription factor 3
ATG4A autophagy related 4A, cysteine peptidase
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
CLTB clathrin, light chain B
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSE cathepsin E
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DMD dystrophin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP14 dual specificity phosphatase 14
EGLN3 egl-9 family hypoxia-inducible factor 3
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LIPG lipase, endothelial
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTCH1 mitochondrial carrier 1
NAMPT nicotinamide phosphoribosyltransferase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
OFD1 oral-facial-digital syndrome 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTHLH parathyroid hormone-like hormone
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP4 secreted frizzled-related protein 4
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SST somatostatin
TAC1 tachykinin, precursor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
TP53BP2 tumor protein p53 binding protein 2
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBE2H ubiquitin-conjugating enzyme E2H
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZYX zyxin

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
AIM1 absent in melanoma 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATPIF1 ATPase inhibitory factor 1
AURKA aurora kinase A
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKLF chemokine-like factor
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
CYBA cytochrome b-245, alpha polypeptide
DACH1 dachshund family transcription factor 1
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM111A family with sequence similarity 111, member A
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
GATA2 GATA binding protein 2
GLOD4 glyoxalase domain containing 4
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSE1 Gse1 coiled-coil protein
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
HELLS helicase, lymphoid-specific
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HLTF helicase-like transcription factor
HMG20B high mobility group 20B
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LAGE3 L antigen family, member 3
LBR lamin B receptor
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MACROD1 MACRO domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MLPH melanophilin
MRPL12 mitochondrial ribosomal protein L12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
OXCT1 3-oxoacid CoA transferase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPA2 pyrophosphatase (inorganic) 2
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB26 RAB26, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS10 regulator of G-protein signaling 10
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TARP TCR gamma alternate reading frame protein
TBC1D16 TBC1 domain family, member 16
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM5 transmembrane protein 5
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZCCHC24 zinc finger, CCHC domain containing 24
ZWINT ZW10 interacting kinetochore protein