BRD-K88510285_B675700.cdx_U937_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K88510285_B675700.cdx_U937_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CNN3 calponin 3, acidic
COL15A1 collagen, type XV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPP4 dipeptidyl-peptidase 4
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GSN gelsolin
HGD homogentisate 1,2-dioxygenase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPG2 heparan sulfate proteoglycan 2
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
IL6ST interleukin 6 signal transducer
JUN jun proto-oncogene
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRP1 neuropilin 1
OSMR oncostatin M receptor
PAWR PRKC, apoptosis, WT1, regulator
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PHACTR2 phosphatase and actin regulator 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTRF polymerase I and transcript release factor
RGCC regulator of cell cycle
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TARS threonyl-tRNA synthetase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ANXA6 annexin A6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BTG2 BTG family, member 2
C11ORF71 chromosome 11 open reading frame 71
C14ORF159 chromosome 14 open reading frame 159
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMXL2 Dmx-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GM2A GM2 ganglioside activator
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GPRC5B G protein-coupled receptor, class C, group 5, member B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ISG15 ISG15 ubiquitin-like modifier
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
LAMC2 laminin, gamma 2
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MLPH melanophilin
MSRB2 methionine sulfoxide reductase B2
NDN necdin, melanoma antigen (MAGE) family member
NREP neuronal regeneration related protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXTR oxytocin receptor
PCYOX1L prenylcysteine oxidase 1 like
PGLS 6-phosphogluconolactonase
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SCD5 stearoyl-CoA desaturase 5
SELPLG selectin P ligand
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A6 solute carrier family 16, member 6
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STK10 serine/threonine kinase 10
STXBP2 syntaxin binding protein 2
TMEM251 transmembrane protein 251
TNS1 tensin 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22