BRD-K88510285_B675700.cdx_T3M10_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K88510285_B675700.cdx_T3M10_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CSRP2 cysteine and glycine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FA2H fatty acid 2-hydroxylase
FASTKD5 FAST kinase domains 5
FZD6 frizzled class receptor 6
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IL17RB interleukin 17 receptor B
IL6 interleukin 6
IRF7 interferon regulatory factor 7
ISLR immunoglobulin superfamily containing leucine-rich repeat
KCTD5 potassium channel tetramerization domain containing 5
KRT6A keratin 6A, type II
LCN2 lipocalin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MMP10 matrix metallopeptidase 10
NDRG1 N-myc downstream regulated 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRIP1 nuclear receptor interacting protein 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RANBP9 RAN binding protein 9
RGS1 regulator of G-protein signaling 1
RPS11 ribosomal protein S11
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SRGN serglycin
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TMEM41B transmembrane protein 41B
TMEM97 transmembrane protein 97
UBE3C ubiquitin protein ligase E3C
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ACTB actin, beta
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
BIK BCL2-interacting killer (apoptosis-inducing)
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC25B cell division cycle 25B
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST1 cystatin SN
CTSZ cathepsin Z
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERLIN1 ER lipid raft associated 1
F12 coagulation factor XII (Hageman factor)
FZD7 frizzled class receptor 7
GSTT1 glutathione S-transferase theta 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMNB1 lamin B1
MAP1B microtubule-associated protein 1B
MGLL monoglyceride lipase
MT1G metallothionein 1G
MT1H metallothionein 1H
MYOF myoferlin
NPTXR neuronal pentraxin receptor
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
OXTR oxytocin receptor
PBX3 pre-B-cell leukemia homeobox 3
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
USP9Y ubiquitin specific peptidase 9, Y-linked
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)