BRD-K88510285_B675700.cdx_SW948_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K88510285_B675700.cdx_SW948_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD11 ankyrin repeat domain 11
ASPN asporin
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD163 CD163 molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DST dystonin
DUSP1 dual specificity phosphatase 1
ETNPPL ethanolamine-phosphate phospho-lyase
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FMO3 flavin containing monooxygenase 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBE1 hemoglobin, epsilon 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KRIT1 KRIT1, ankyrin repeat containing
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
NQO2 NAD(P)H dehydrogenase, quinone 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PERP PERP, TP53 apoptosis effector
PHKG2 phosphorylase kinase, gamma 2 (testis)
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SP140L SP140 nuclear body protein-like
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UFD1L ubiquitin fusion degradation 1 like (yeast)
WARS tryptophanyl-tRNA synthetase
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIRC5 baculoviral IAP repeat containing 5
BRD3 bromodomain containing 3
CANT1 calcium activated nucleotidase 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COA3 cytochrome c oxidase assembly factor 3
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CSK c-src tyrosine kinase
CTSC cathepsin C
CYB561 cytochrome b561
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DOK4 docking protein 4
DUSP6 dual specificity phosphatase 6
ENDOD1 endonuclease domain containing 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
GTF3A general transcription factor IIIA
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
KAZN kazrin, periplakin interacting protein
KIAA0226L KIAA0226-like
LAMP1 lysosomal-associated membrane protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPCAT1 lysophosphatidylcholine acyltransferase 1
LY6E lymphocyte antigen 6 complex, locus E
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLEC malectin
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY neuropeptide Y
NSG1 neuron specific gene family member 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCGF2 polycomb group ring finger 2
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PPAP2C phosphatidic acid phosphatase type 2C
PRDX2 peroxiredoxin 2
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSENEN presenilin enhancer gamma secretase subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTCH1 patched 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPIA ribose 5-phosphate isomerase A
RPN2 ribophorin II
SCAND1 SCAN domain containing 1
SEPT9 septin 9
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF7 serine/arginine-rich splicing factor 7
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8