BRD-K88510285_B675700.cdx_SW620_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K88510285_B675700.cdx_SW620_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP5 charged multivesicular body protein 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EGFR epidermal growth factor receptor
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FN1 fibronectin 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL18 interleukin 18
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
JOSD1 Josephin domain containing 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT6B keratin 6B, type II
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPC1 Niemann-Pick disease, type C1
OAT ornithine aminotransferase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PHGDH phosphoglycerate dehydrogenase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RB1CC1 RB1-inducible coiled-coil 1
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
RPL10 ribosomal protein L10
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC3 structural maintenance of chromosomes 3
SOAT1 sterol O-acyltransferase 1
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TES testin LIM domain protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ANXA6 annexin A6
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDK6 cyclin-dependent kinase 6
CIRBP cold inducible RNA binding protein
CLEC11A C-type lectin domain family 11, member A
COG4 component of oligomeric golgi complex 4
CST1 cystatin SN
CST3 cystatin C
CYBA cytochrome b-245, alpha polypeptide
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA5 defensin, alpha 5, Paneth cell-specific
DPEP1 dipeptidase 1 (renal)
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FGFR4 fibroblast growth factor receptor 4
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8H golgin A8 family, member H
GPM6A glycoprotein M6A
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KDM4B lysine (K)-specific demethylase 4B
KIAA0485 uncharacterized LOC57235
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL1 lysyl oxidase-like 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
METTL7A methyltransferase like 7A
MRPL57 mitochondrial ribosomal protein L57
MSRB2 methionine sulfoxide reductase B2
NDRG2 NDRG family member 2
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFA platelet-derived growth factor alpha polypeptide
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRR7 proline rich 7 (synaptic)
PYCARD PYD and CARD domain containing
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS26 ribosomal protein S26
S100A8 S100 calcium binding protein A8
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT2 SID1 transmembrane family, member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TGOLN2 trans-golgi network protein 2
THAP11 THAP domain containing 11
TPM2 tropomyosin 2 (beta)
TSPAN5 tetraspanin 5
WFS1 Wolfram syndrome 1 (wolframin)
WIF1 WNT inhibitory factor 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF580 zinc finger protein 580
ZNF652 zinc finger protein 652