BRD-K88510285_B675700.cdx_SNUC4_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K88510285_B675700.cdx_SNUC4_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CPM carboxypeptidase M
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DST dystonin
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FBXL12 F-box and leucine-rich repeat protein 12
FBXO11 F-box protein 11
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLA galactosidase, alpha
GPR183 G protein-coupled receptor 183
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
LYZ lysozyme
MARS methionyl-tRNA synthetase
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPPED2 metallophosphoesterase domain containing 2
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RLF rearranged L-myc fusion
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TBX3 T-box 3
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CLCA1 chloride channel accessory 1
CST6 cystatin E/M
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DAPK1 death-associated protein kinase 1
ENOPH1 enolase-phosphatase 1
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
KRT20 keratin 20, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
MARCKS myristoylated alanine-rich protein kinase C substrate
NRN1 neuritin 1
PAEP progestagen-associated endometrial protein
PLK1 polo-like kinase 1
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF167 ring finger protein 167
S100A7 S100 calcium binding protein A7
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT8 septin 8
SETBP1 SET binding protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97