BRD-K88510285_B675700.cdx_SKMEL28_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K88510285_B675700.cdx_SKMEL28_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC3B C-type lectin domain family 3, member B
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
FBXO21 F-box protein 21
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS6 growth arrest-specific 6
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
ITM2C integral membrane protein 2C
KLF4 Kruppel-like factor 4 (gut)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDNF neuron-derived neurotrophic factor
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RTN2 reticulon 2
SEC63 SEC63 homolog (S. cerevisiae)
SFTPC surfactant protein C
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TARS threonyl-tRNA synthetase
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM30B transmembrane protein 30B
TMEM41B transmembrane protein 41B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUFT1 tuftelin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP12 A kinase (PRKA) anchor protein 12
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOD apolipoprotein D
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BCL2A1 BCL2-related protein A1
CCNA2 cyclin A2
CD320 CD320 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTL1 cytokine-like 1
DUSP6 dual specificity phosphatase 6
FYN FYN proto-oncogene, Src family tyrosine kinase
GATA3 GATA binding protein 3
GTF3A general transcription factor IIIA
HLF hepatic leukemia factor
HN1 hematological and neurological expressed 1
IFITM2 interferon induced transmembrane protein 2
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JADE2 jade family PHD finger 2
KRT5 keratin 5, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LY6E lymphocyte antigen 6 complex, locus E
MLANA melan-A
MXRA7 matrix-remodelling associated 7
NPY neuropeptide Y
OXTR oxytocin receptor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLP1 proteolipid protein 1
PMEL premelanosome protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
RPL36 ribosomal protein L36
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SELL selectin L
SEPT9 septin 9
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM251 transmembrane protein 251
TNC tenascin C
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TYR tyrosinase
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3