BRD-K88510285_B675700.cdx_SKMEL1_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K88510285_B675700.cdx_SKMEL1_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACTB actin, beta
BAG3 BCL2-associated athanogene 3
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CLDN10 claudin 10
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
E2F2 E2F transcription factor 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN5 fibulin 5
FKBP5 FK506 binding protein 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KLK11 kallikrein-related peptidase 11
KNG1 kininogen 1
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MFSD10 major facilitator superfamily domain containing 10
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLEC plectin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP4 secreted frizzled-related protein 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG6 adhesion G protein-coupled receptor G6
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
APOLD1 apolipoprotein L domain containing 1
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C3ORF14 chromosome 3 open reading frame 14
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2A cyclin-dependent kinase inhibitor 2A
CPE carboxypeptidase E
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DARS aspartyl-tRNA synthetase
DPT dermatopontin
EFNB2 ephrin-B2
EFS embryonal Fyn-associated substrate
FST follistatin
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INTS6 integrator complex subunit 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL9 kelch-like family member 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NXN nucleoredoxin
PBX1 pre-B-cell leukemia homeobox 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTTG1 pituitary tumor-transforming 1
RBPMS RNA binding protein with multiple splicing
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX11 SRY (sex determining region Y)-box 11
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM47 transmembrane protein 47
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB2 tribbles pseudokinase 2
ZNF395 zinc finger protein 395