BRD-K88510285_B675700.cdx_SKM1_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K88510285_B675700.cdx_SKM1_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHCYL1 adenosylhomocysteinase-like 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLEC5A C-type lectin domain family 5, member A
COL18A1 collagen, type XVIII, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CSDE1 cold shock domain containing E1, RNA-binding
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FILIP1L filamin A interacting protein 1-like
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRB7 growth factor receptor-bound protein 7
HDLBP high density lipoprotein binding protein
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMA4 laminin, alpha 4
LOXL2 lysyl oxidase-like 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHB Src homology 2 domain containing adaptor protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM30B transmembrane protein 30B
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
ZNF165 zinc finger protein 165
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
AQP3 aquaporin 3 (Gill blood group)
ARF3 ADP-ribosylation factor 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATMIN ATM interactor
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BST2 bone marrow stromal cell antigen 2
CCL19 chemokine (C-C motif) ligand 19
CCND3 cyclin D3
CD37 CD37 molecule
CD47 CD47 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHSY1 chondroitin sulfate synthase 1
CNPY2 canopy FGF signaling regulator 2
COMMD8 COMM domain containing 8
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP7 dual specificity phosphatase 7
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
FAM65B family with sequence similarity 65, member B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GTF2A2 general transcription factor IIA, 2, 12kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LDHB lactate dehydrogenase B
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPXN leupaxin
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYD88 myeloid differentiation primary response 88
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NRN1 neuritin 1
PCYOX1L prenylcysteine oxidase 1 like
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF167 ring finger protein 167
RPA3 replication protein A3, 14kDa
RPL37A ribosomal protein L37a
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEPP1 selenoprotein P, plasma, 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM50A transmembrane protein 50A
TNC tenascin C
TNS3 tensin 3
WASF3 WAS protein family, member 3
XPO7 exportin 7
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)