BRD-K88510285_B675700.cdx_SKLU1_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K88510285_B675700.cdx_SKLU1_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BPI bactericidal/permeability-increasing protein
C3 complement component 3
CADM1 cell adhesion molecule 1
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CPE carboxypeptidase E
CPM carboxypeptidase M
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
DEFA4 defensin, alpha 4, corticostatin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK4 dedicator of cytokinesis 4
EPAS1 endothelial PAS domain protein 1
FASTKD5 FAST kinase domains 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GCLC glutamate-cysteine ligase, catalytic subunit
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
KLK5 kallikrein-related peptidase 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM2 phosphomannomutase 2
PTN pleiotrophin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SOD2 superoxide dismutase 2, mitochondrial
TACSTD2 tumor-associated calcium signal transducer 2
TRIM2 tripartite motif containing 2
UBB ubiquitin B
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACACB acetyl-CoA carboxylase beta
B3GNT1
BEX1 brain expressed, X-linked 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DUOX2 dual oxidase 2
EMP3 epithelial membrane protein 3
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCHFR GTP cyclohydrolase I feedback regulator
GOLGA8A golgin A8 family, member A
GPM6A glycoprotein M6A
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
JADE2 jade family PHD finger 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF2 Kruppel-like factor 2
MED1 mediator complex subunit 1
MPHOSPH9 M-phase phosphoprotein 9
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP4 poly (ADP-ribose) polymerase family, member 4
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBLD phenazine biosynthesis-like protein domain containing
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLS1 plastin 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
S100A7 S100 calcium binding protein A7
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TOB1 transducer of ERBB2, 1
TRAM2 translocation associated membrane protein 2
TRIM14 tripartite motif containing 14
ZBTB18 zinc finger and BTB domain containing 18
ZMYND8 zinc finger, MYND-type containing 8