BRD-K88510285_B675700.cdx_NOMO1_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K88510285_B675700.cdx_NOMO1_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD4 abhydrolase domain containing 4
AEBP1 AE binding protein 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ECM1 extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NRCAM neuronal cell adhesion molecule
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
S100P S100 calcium binding protein P
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STC2 stanniocalcin 2
STXBP6 syntaxin binding protein 6 (amisyn)
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TARS threonyl-tRNA synthetase
TIMP3 TIMP metallopeptidase inhibitor 3
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTSG cathepsin G
CTSS cathepsin S
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EMP3 epithelial membrane protein 3
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
ETFB electron-transfer-flavoprotein, beta polypeptide
GOLGA8H golgin A8 family, member H
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
HOXC6 homeobox C6
IFITM2 interferon induced transmembrane protein 2
JADE2 jade family PHD finger 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LY75 lymphocyte antigen 75
MACF1 microtubule-actin crosslinking factor 1
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
NUP85 nucleoporin 85kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZK1 PDZ domain containing 1
PLAC8 placenta-specific 8
PLEK pleckstrin
PRKCB protein kinase C, beta
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
RFC2 replication factor C (activator 1) 2, 40kDa
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF11 serine/arginine-rich splicing factor 11
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TXNIP thioredoxin interacting protein
UPK1B uroplakin 1B
ZBTB18 zinc finger and BTB domain containing 18
ZMYND8 zinc finger, MYND-type containing 8